Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux.
10.5223/pghn.2017.20.3.153
- Author:
Frederick W WOODLEY
1
;
Melissa MOORE-CLINGENPEEL
;
Rodrigo Strehl MACHADO
;
Christopher J NEMASTIL
;
Sudarshan R JADCHERLA
;
Don HAYES
;
Benjamin T KOPP
;
Ajay KAUL
;
Carlo DI LORENZO
;
Hayat MOUSA
Author Information
1. Division of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, OH, USA. Frederick.Woodley@nationwidechildrens.org
- Publication Type:Original Article
- Keywords:
Chemical clearance;
Acid neutralization;
Impedance;
Cystic fibrosis;
Child
- MeSH:
Child*;
Cystic Fibrosis*;
Electric Impedance;
Gastric Acid;
Genotype;
Humans;
Reference Values;
Saliva;
Sample Size
- From:Pediatric Gastroenterology, Hepatology & Nutrition
2017;20(3):153-159
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Acid neutralization during chemical clearance is significantly prolonged in children with cystic fibrosis, compared to symptomatic children without cystic fibrosis. The absence of available reference values impeded identification of abnormal findings within individual patients with and without cystic fibrosis. The present study aimed to test the hypothesis that significantly more children with cystic fibrosis have acid neutralization durations during chemical clearance that fall outside the physiological range. METHODS: Published reference value for acid neutralization duration during chemical clearance (determined using combined impedance/pH monitoring) was used to assess esophageal acid neutralization efficiency during chemical clearance in 16 children with cystic fibrosis (3 to <18 years) and 16 age-matched children without cystic fibrosis. RESULTS: Duration of acid neutralization during chemical clearance exceeded the upper end of the physiological range in 9 of 16 (56.3%) children with and in 3 of 16 (18.8%) children without cystic fibrosis (p=0.0412). The likelihood ratio for duration indicated that children with cystic fibrosis are 2.1-times more likely to have abnormal acid neutralization during chemical clearance, and children with abnormal acid neutralization during chemical clearance are 1.5-times more likely to have cystic fibrosis. CONCLUSION: Significantly more (but not all) children with cystic fibrosis have abnormally prolonged esophageal clearance of acid. Children with cystic fibrosis are more likely to have abnormal acid neutralization during chemical clearance. Additional studies involving larger sample sizes are needed to address the importance of genotype, esophageal motility, composition and volume of saliva, and gastric acidity on acid neutralization efficiency in cystic fibrosis children.
