Acellular Scaffolds as Innovative Biomaterial Platforms for the Management of Diabetic Wounds
10.1007/s13770-021-00344-1
- Author:
Vyshnavi TALLAPANENI
1
;
C. KALAIVANI
;
Divya PAMU
;
Lavanya MUDE
;
Sachin Kumar SINGH
;
Veera Venkata Satyanarayana REDDY KARRI
Author Information
1. Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India
- Publication Type:REVIEW ARTICLE
- From:
Tissue Engineering and Regenerative Medicine
2021;18(5):713-734
- CountryRepublic of Korea
- Language:English
-
Abstract:
Diabetic wound (DW) is one of the leading complications of patients having a long history of uncontrolled diabetes. Moreover, it also imposes an economic burden on people suffering from wounds to manage the treatment. The major impending factors in the treatment of DW are infection, prolonged inflammation and decreased oxygen levels. Since these non-healing wounds are associated with an extended recovery period, the existing therapies provide treatment for a limited period only. The areas covered in this review are general sequential events of wound healing along with DW’s pathophysiology, the origin of DW and success, as well as limitations of existing therapies. This systematic review’s significant aspect is to highlight the fabrication, characterization and applications of various acellular scaffolds used to heal DW. In addition to that, cellular scaffolds are also described to a limited extent.
