The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study.
- Author:
So Yong PARK
1
;
Jong Won PARK
;
Yeon Mok OH
;
Yang Keun RHEE
;
Young Mok LEE
;
Yong Bum PARK
;
Seong Yong LIM
Author Information
- Publication Type:Original Article
- Keywords: Obesity; Bronchial Hyperresponsiveness; Dermatitis, Atopic
- MeSH: Asthma; Body Mass Index; Cough; Dermatitis, Atopic; Developed Countries; Eosinophilia; Eosinophils; Humans; Immunoglobulin E; Incidence; Obesity; Prevalence; Retrospective Studies; Skin; Vital Capacity
- From:Tuberculosis and Respiratory Diseases 2011;71(1):24-29
- CountryRepublic of Korea
- Language:Korean
- Abstract: BACKGROUND: The rising prevalence of asthma worldwide may be associated with the rising prevalence of obesity in developed nations. Although several studies have suggested a relationship between asthma and obesity, controversy still remains. The aim of this study was to examine the relationship between obesity and asthmatic factors such as atopy, eosinophilia, serum total Ig E and bronchial hyperresponsiveness in chronic cough patients. METHODS: This study was a retrospective, observational study in two centers done between January 2007 and June 2008. The subjects included individuals who had a chronic cough. We examined body mass index (BMI) to measure obesity and pulmonary function. We did a metacholine provocation test for airway hyperresponsiveness (AHR), a skin prick test for atopy, and tests for blood eosinophils and serum IgE. RESULTS: A total of 1022 subjects were included. Airway hyperresponsiveness was not related with obesity (p=0.06), and atopy incidence was significant higher in non obese patients (p=0.00). There was no significant difference in serum IgE and blood eosinophil counts between obese and non obese patients. Forced expiratory volue in one second (FEV1)/forced vital capacity (FVC) was significantly reduced in obese patients (p=0.03), but FEV1 and FVC were no significant difference between obese and non obese patients. CONCLUSION: There is no relationship between obesity and bronchial hyperresponsiveness. The nonobese group appears to have more atopy. The relationship between obesity and bronchial hyperresponsiveness and atopy need further investigation.
