Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment
10.1007/s13770-020-00322-z
- Author:
Donggang MOU
1
;
Qunying YU
;
Jimei ZHANG
;
Jianping ZHOU
;
Xinmin LI
;
Weiyi ZHUANG
;
Xuming YANG
Author Information
1. Department of Orthopedics, Yan’an Hospital Affiliated to Kunming Medical University, Kunming 650035, People’s Republic of China
- Publication Type:ORIGINAL ARTICLE
- From:
Tissue Engineering and Regenerative Medicine
2021;18(1):113-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND:Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment.Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the difficulty of longterm maintenance of efficacy.
METHODS:In this study, an injectable and self-healing hydrogel was synthesized by in situ crosslinking of N-carboxyethyl chitosan (N-chitosan), adipic acid dihydrazide (ADH), and hyaluronic acid–aldehyde (HA-ALD).
RESULTS:This supramolecular hydrogel sustains good biocompatibility for chondrocytes. Intra-articular injection of this novel hydrogel can significantly alleviate the local inflammation microenvironment in knee joints, through inhibiting the inflammatory cytokines (such as TNF-a, IL-1b, IL-6 and IL-17) in the synovial fluid and cartilage at 2- and even 12-weeks post-injection. Histological and behavioral test indicated that hydrogel injection protected cartilage destruction and relieved pain in OA rats, in comparison to HA injection.
CONCLUSION:This kind of novel hydrogel, which is superior to the traditional HA injection, reveals a great potential for the treatment of OA.
