Association between Metabolic Syndrome and Plasma Homocysteine among Korean Adults.
- Author:
Kyung Sun YOON
1
;
Hee Jeong CHOI
;
Jee Aee IM
;
Joo Ho YOON
;
Sang Hwan KIM
Author Information
1. Department of Family Medicine, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea. fanin@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
homocysteine;
insulin resistance;
metabolic syndrome
- MeSH:
Adult;
Alcohol Drinking;
Apolipoprotein A-I;
Atherosclerosis;
Blood Pressure;
Cardiovascular Diseases;
Cholesterol;
Dyslipidemias;
Fasting;
Glucose;
Health Promotion;
Homocysteine;
Humans;
Hyperglycemia;
Hypertension;
Insulin;
Insulin Resistance;
Life Style;
Lipoproteins;
Male;
Obesity, Abdominal;
Physical Examination;
Plasma;
Risk Factors;
Smoke;
Smoking;
Triglycerides;
Waist Circumference;
Surveys and Questionnaires
- From:Journal of the Korean Academy of Family Medicine
2008;29(7):499-505
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Elevated plasma homocysteine is an independent risk factor for cardiovascular diseases caused by atherosclerosis. Previous studies have shown that plasma homocysteine is associated with components of the metabolic syndrome such as hypertension, insulin resistance, and dyslipidemia. In this study, we investigated the association between the plasma homocysteine levels and the metabolic syndrome on Korean adults. METHODS: The study group with the metabolic syndrome and the control group without the metabolic syndrome were selected from the examinees of equivalent age and gender in the Health Promotion Center. Among the subjects, 107 adults with the metabolic syndrome and 123 adults without the metabolic syndrome were categorized into the study and the control groups, respectively. Medical history, medication, and life style were recorded through a questionnaire and physical examination was performed on all subjects. We measured fasting glucose, total cholesterol, triglycerides, high-density lipoprotein, hs-CRP, homocysteine levels and others by blood sampling. The metabolic syndrome was defined by the criteria for clinical diagnosis of the metabolic syndrome by AHA/NHLBI. RESULTS: The mean ages in the study group and the control group were 54.6+/-9.3 and 54.6+/-8.7 years, respectively, and the numbers of males 29 (27.1%) and 39 (31.7%), respectively. The plasma homocysteine was observed to be positively correlated with age, waist circumference, diastolic blood pressure, apolipoprotein A-1, fasting glucose, fasting insulin, HOMA-IR, and hs-CRP. Among the components of the metabolic syndrome, hypertension showed a strong correlation with the levels of the plasma homocysteine (10.62+/-3.92 micronmol/L vs. 9.09+/- 2.63 micronmol/L, P=0.001), whereas hyperglycemia, abdominal obesity, and dyslipidemia did not correlate with the levels of plasma homocysteine. Adjusted homocysteine levels to age, gender, alcohol drinking history, and smoking history was still higher in the study group compared to those in the control group (10.320+/-0.290 micronmol/L vs. 10.320+/-0.290 micronmol/L, P=0.017). CONCLUSION: The results indicate that the metabolic syndrome leads to a higher level of homocysteine in adults after adjustment to age, gender, alcohol drinking history, and smoking history.
