Anticoccidial Activity of Berberine against Eimeria-Infected Chickens
10.3347/kjp.2021.59.4.403
- Author:
Binh Thanh NGUYEN
1
;
Rochelle Alipio FLORES
;
Paula Leona Taymen CAMMAYO
;
Suk KIM
;
Woo Hyun KIM
;
Wongi MIN
Author Information
1. College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Korea
- Publication Type:Brief Communication
- From:The Korean Journal of Parasitology
2021;59(4):403-408
- CountryRepublic of Korea
- Language:English
-
Abstract:
Avian coccidiosis has a major economic impact on the poultry industry, it is caused by 7 species of Eimeria, and has been primarily controlled using chemotherapeutic agents. Due to the emergence of drug-resistant strains, alternative control strategies are needed. We assessed anticoccidial effects of berberine-based diets in broiler chickens following oral infection with 5 Eimeria species (E. acervulina, E. maxima, E. tenella, E. mitis, and E. praecox). When 0.2% berberine, a concentration that does not affect weight gain, was added to the diet, the 4 groups infected with E. acervulina, E. tenella, E. mitis, or E. praecox showed significant reductions in fecal oocyst shedding (P<0.05) compared to their respective infected and untreated controls. In chickens treated 0.5% berberine instead of 0.2% and infected with E. maxima, fecal oocyst production was significantly reduced, but body weight deceased, indicating that berberine treatment was not useful for E. maxima infection. Taken together, these results illustrate the applicability of berberine for prophylactic use to control most Eimeria infections except E. maxima. Further studies on the mechanisms underlying the differences in anticoccidial susceptibility to berberine, particularly E. maxima, are remained.
