Seven Steps to the Diagnosis of NSAIDs Hypersensitivity: How to Apply a New Classification in Real Practice?.
10.4168/aair.2015.7.4.312
- Author:
Marek L KOWALSKI
1
;
Joanna S MAKOWSKA
Author Information
1. Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, Lodz, Poland. marek.kowalski@csk.umed.lodz.pl
- Publication Type:Review
- Keywords:
Nonsteroidal anti-inflammatory drugs;
NSAID-induced hypersensitivity;
aspirin hypersensitivity;
aspirin;
drug allergy
- MeSH:
Anaphylaxis;
Anti-Inflammatory Agents, Non-Steroidal*;
Aspirin;
Classification*;
Diagnosis*;
Drug Hypersensitivity;
Exanthema;
Humans;
Hypersensitivity*
- From:Allergy, Asthma & Immunology Research
2015;7(4):312-320
- CountryRepublic of Korea
- Language:English
-
Abstract:
Frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) has been paralleled by increasing occurrence of adverse reactions, which vary from mild local skin rashes or gastric irritation to severe, generalized symptoms and even life-threatening anaphylaxis. NSAID-induced hypersensitivity reactions may involve both immunological and non-immunological mechanisms and should be differentiated from type A adverse reactions. Clinical diagnosis and effective management of a hypersensitive patient cannot be achieved without identifying the underlying mechanism. In this review, we discuss the current classification of NSAID-induced adverse reactions and propose a practical diagnostic algorithm that involves 7 steps leading to the determination of the type of NSAID-induced hypersensitivity and allows for proper patient management.
