Association between Dementia and Clinical Outcome after COVID-19: A Nationwide Cohort Study with Propensity Score Matched Control in South Korea
- Author:
Sheng-Min WANG
1
;
See Hyun PARK
;
Nak-Young KIM
;
Dong Woo KANG
;
Hae-Ran NA
;
Yoo Hyun UM
;
Seunghoon HAN
;
Sung-Soo PARK
;
Hyun Kook LIM
Author Information
- Publication Type:Original Article
- From:Psychiatry Investigation 2021;18(6):523-529
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objective:Despite a high prevalence of dementia in older adults hospitalized with severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2), or so called COVID-19, research investigating association between preexisting diagnoses of dementia and prognosis of COVID-19 is scarce. We aimed to investigate treatment outcome of patients with dementia after COVID-19.
Methods:We explored a nationwide cohort with a total of 2,800 subjects older than 50 years who were diagnosed with COVID-19 between January and April 2020. Among them, 223 patients had underlying dementia (dementia group). We matched 1:1 for each dementia- non-dementia group pair yielding 223 patients without dementia (no dementia group) using propensity score matching.
Results:Mortality rate after COVID-19 was higher in dementia group than in no dementia group (33.6% vs. 20.2%, p=0.002). Dementia group had higher proportion of patients requiring invasive ventilatory support than no dementia group (34.1% vs. 22.0%, p=0.006). Multivariable analysis showed that dementia group had a higher risk of mortality than no dementia group (odds ratio=3.05, p<0.001). We also found that patients in dementia group had a higher risk of needing invasive ventilatory support than those in no dementia group.
Conclusion:Our results suggest that system including strengthen quarantines are required for patients with dementia during the COVID- 19 pandemic.
