Medullary thyroid carcinoma: a 30-year experience at one institution in Korea.
10.4174/astr.2016.91.6.278
- Author:
Cho Rok LEE
1
;
Sohee LEE
;
Haiyoung SON
;
Eunjeong BAN
;
Sang Wook KANG
;
Jandee LEE
;
Jong Ju JEONG
;
Kee Hyun NAM
;
Woong Youn CHUNG
;
Cheong Soo PARK
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. jungjongj@yuhs.ac
- Publication Type:Original Article
- Keywords:
Familial medullary thyroid carcinoma;
Prognosis;
Survival
- MeSH:
Disease-Free Survival;
Humans;
Korea*;
Multivariate Analysis;
Neoplasm Metastasis;
Prognosis;
Retrospective Studies;
Survival Rate;
Tertiary Care Centers;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Annals of Surgical Treatment and Research
2016;91(6):278-287
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. METHODS: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. RESULTS: In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0.001). However, the hereditary group had more tumor multiplicity (P < 0.001) and bilaterality (P < 0.001). Neither survival rate was significantly different between the sporadic and hereditary groups (P = 0.775 and P = 0.866). By multivariate analysis, distant metastasis was a significant prognostic factor for overall and progression-free survival. CONCLUSION: In general, patients with MTC have favorable outcomes. Distant metastasis appears to be the strongest predictor of overall and progression-free survival.
