Effects of postoperative parenteral nutrition with different lipid emulsions in patients undergoing major abdominal surgery.
10.4174/astr.2016.91.6.309
- Author:
Seher DEMIRER
1
;
Ali SAPMAZ
;
Ahmet Serdar KARACA
;
Ilknur KEPENEKCI
;
Semih AYDINTUG
;
Deniz BALCI
;
Pinar SONYUREK
;
Kenan KOSE
Author Information
1. Department of General Surgery, Ankara University School of Medicine, Ankara, Turkey.
- Publication Type:Original Article
- Keywords:
Lipid emulsions;
Inflammatory response;
Total antioxidant status
- MeSH:
Blood Cells;
Body Weight;
Emulsions*;
Fish Oils;
Humans;
Interleukin-6;
International Normalized Ratio;
Necrosis;
Olive Oil;
Parenteral Nutrition*;
Parenteral Nutrition, Total;
Prealbumin;
Prothrombin Time;
Soybean Oil;
Soybeans;
Thiobarbituric Acid Reactive Substances;
Thromboplastin;
Transferrin;
Triglycerides
- From:Annals of Surgical Treatment and Research
2016;91(6):309-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study was designed to investigate the effects of total parenteral nutrition (PN) using different lipid emulsions in patients undergoing major abdominal surgery. METHODS: Fifty-two patients were randomized to receive soybean oil + medium chain triglycerides (MCT) (group I), soybean oil + olive oil (group II), soybean oil + olive oil + fish oil (group III) as a lipid source. PN was started on postoperative day 1 and patients were maintained on PN for a minimum period of 4 days. Laboratory variables (CRP, prealbumin, transferrin) were measured before surgery and on postoperative days. RESULTS: Three treatment groups were included in the study. Patients in group I received long chain triglycerides (LCT) + LCT/MCT emulsion (%75 LCT + %25 LCT/MCT); Patients in group II received olive oil based emulsion (80% olive oil + 20% soybean oil, ClinOleic); Patients in group III received fish oil in addition to olive oil based emulsion (%85 ClinOleic + %15 Omegaven; Fresenius Kabi). The following 14 parameters were assessed: body weight, CRP, prealbumin, transferrin, tumor necrosis factor-α, interleukin-6, total antioxidant status, thiobarbituric acid reactive substances, oxidized low density lipoprotein-2, complete blood cell, international normalized ratio, D-dimer, activated partially thromboplastin time, prothrombin time. All other parameters showed no differences among the groups. CONCLUSION: The results of our trial demonstrate a potential beneficial effect of soybean oil/olive oil based lipid emulsions for use in PN regarding inflammatory response and oxidant capacity in the treatment of patients.
