Multiple endocrine neoplasia type 1 with anterior mediastinal parathyroid adenoma: successful localization using Tc-99m sestamibi SPECT/CT.
10.4174/astr.2016.91.6.323
- Author:
Hye Lim PARK
1
;
Ie Ryung YOO
;
Sung Hoon KIM
;
Sohee LEE
Author Information
1. Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. iryoo@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Multiple endocrine neoplasia type 1;
Parathyroid neoplasms;
Single-photon emission-computed tomography;
Technetium-99m sestamibi
- MeSH:
Female;
Humans;
Hyperparathyroidism;
Male;
Middle Aged;
Multiple Endocrine Neoplasia Type 1*;
Multiple Endocrine Neoplasia*;
Parathyroid Glands;
Parathyroid Neoplasms*;
Parathyroidectomy;
Radionuclide Imaging;
Siblings;
Thoracic Surgery, Video-Assisted;
Tomography, Emission-Computed, Single-Photon
- From:Annals of Surgical Treatment and Research
2016;91(6):323-326
- CountryRepublic of Korea
- Language:English
-
Abstract:
The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT). She underwent total parathyroidectomy with video-assisted thoracoscopic surgery on an anterior mediastinal mass. Anterior mediastinal parathyroid adenoma in MEN1 patients is rare. Precise localization of an ectopic parathyroid gland with Tc-99m sestamibi SPECT/CT can lead to successful treatment of hyperparathyroidism. This is the first reported case in the literature of mediastinal parathyroid adenoma in MEN1 patient visualized by Tc-99m sestamibi SPECT/CT.
