Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.

Author: Mulyadi TANJUNG ¹ ; Muhammad Fajar ALDIN ; Tjitjik Srie TJAHJANDARIE ; Devina Oktari RAHAYU ; Alfiah Nur Irza GUNAWAN ; Ratih Dewi SAPUTRI
Author Information

1. Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
Publication Type:Original Article
From:Natural Product Sciences 2021;27(3):172-175
CountryRepublic of Korea
Language:English
Abstract: Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLacells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 µg/mL,respectively. Conversely, all of the isolates were inactive towards HeLa cells.