Melixyloidin, A New Acridone Alkaloid from Melicope xanthoxyloides Leaves
- Author:
Ratih Dewi SAPUTRI
1
;
Mulyadi TANJUNG
;
Tjitjik Srie TJAHJANDARIE
Author Information
- Publication Type:Original Article
- From:Natural Product Sciences 2021;27(3):183-186
- CountryRepublic of Korea
- Language:English
- Abstract: A new acridone alkaloid, melixyloidin (1), and two known alkaloids (2-3) were isolated from Melicope xanthoxyloides (F. Muell) T.G. Hartley leaves. The structure of melixyloidin were elucidated using NMR spectra and high-resolution ESIMS data. Acridone alkaloids 1-3 were evaluated against MCF-7 and HeLacells. 1,3,4-Trimethoxy-10-methylacridin-9-one (2) showed potent cytotoxic activity against MCF-7 cells with an IC50 value of 5.31 μM.
