A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves

Author: Sofa FAJRIAH ¹ ; Megawati MEGAWATI ; Akhmad DARMAWAN ; Puspa Dewi N. LOTULUNG ; Salahuddin SALAHUDDIN ; Muhammad HANAFI
Author Information

1. Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, 15314 Banten, Indonesia
Publication Type:Original Article
From:Natural Product Sciences 2020;26(4):279-282
CountryRepublic of Korea
Language:English
Abstract: Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, β-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 ㎛