Consoramides A–C, New Zwitterionic Alkaloids from the Fungus Irpex consors
10.1080/12298093.2021.1924926
- Author:
Ji-Yul KIM
1
;
Dae-Won KI
;
Yoon-Ju LEE
;
Lee Su HA
;
E-Eum WOO
;
In-Kyoung LEE
;
Bong-Sik YUN
Author Information
1. Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, Korea
- Publication Type:RESEARCH NOTE
- From:Mycobiology
2021;49(4):434-437
- CountryRepublic of Korea
- Language:English
-
Abstract:
In our ongoing search for new secondary metabolites from fungi, a basidiomycete fungus Irpex consors was selected for mycochemical investigation, and three new zwitterionic alkaloids (1-3) and five known compounds (4-8) were isolated from the culture broth (16 l) of I. consors. The culture filtrate was fractionated by a series of column chromatography including Diaion HP-20, silica gel, and Sephadex LH-20, Sep-Pak C18 cartridge, medium pressure liquid chromatography (MPLC), and high pressure liquid chromatography (HPLC) to yield eight compounds (1-8). The structures of the isolated compounds were elucidated by the interpretation of nuclear magnetic resonance (NMR) spectra and high-resolution mass spectrometry (HR-MS). Their antioxidant and antibacterial activities were examined. The zwitterionic structures of three new sesquiterpene alkaloids (1-3) were determined together with five known compounds identified as stereumamide E (4), stereumamide G (5), stereumamide H (6), stereumamide D (7), and sterostrein H (8). This is the first report of the zwitterionic alkaloids in the culture broth of I. consors. Three new zwitterionic alkaloids were named as consoramides A–C (1-3).
