Sasa quelpaertensis Nakai ethyl acetate fraction protects the liver against chronic alcohol-induced liver injury and fat accumulation in mice
10.14405/kjvr.2020.60.4.215
- Author:
Areum KIM
1
;
Youngju LEE
;
Kalahe Hewage Iresha Nadeeka MADUSHANI HERATH
;
Hyo Jin KIM
;
Jiwon YANG
;
Ju-Sung KIM
;
Youngheun JEE
Author Information
1. Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University, Jeju 63243, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Korean Journal of Veterinary Research
2020;60(4):215-223
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sasa (S.) quelpaertensis Nakai (Korean name, Jeju-Joritdae), which has anti-oxidative and anti-inflammatory activities, is a type of bamboo grass distributed widely in Jeju Island, Korea. S. quelpaertensis leaves are used for therapeutic purposes in traditional Korean medicine. This study examined the hepatoprotective effects of the S. quelpaertensis ethyl acetate fraction (SQEA) in a mouse model to mimic alcoholic liver damage. The mice were administered orally with 30% alcohol (5 g/kg) once per day with or without SQEA treatments (100 and 200 mg/kg) for 14 days consecutively. Alcohol consumption increased the serum alcohol content and histopathological changes but reduced the liver weight. Moreover, the livers of the alcohol group exhibited the accumulation of malondialdehyde and cytochrome P450 2E1 (CYP2E1), and lipid droplet coating protein perilipin-2. On the other hand, SQEA dosedependently attenuated the alcohol-induced serum ethanol content and liver histopathological changes but increased the liver weight.Moreover, SQEA attenuated the level of CYP2E1 and inhibited alcohol-induced lipogenesis in the liver via decreased perilipin-2 expression. These results suggest that SQEA can provide a potent way to reduce the liver damage caused by alcohol consumption.
