Surgical Treatment for Intrahepatic Cholangiocarcinoma.
- Author:
Eun Young KIM
1
;
Byoung Kuk YAE
;
Mun Sup SIM
Author Information
1. Department of Surgery, Pusan National University College of Medicine, Busan, Korea. simms@hyowon.pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Intraheptic cholangiocarcinoma
- MeSH:
Adenocarcinoma;
Angiography;
Bile Ducts, Intrahepatic;
Cholangiocarcinoma*;
Clonorchiasis;
Diagnosis;
Female;
Hepatic Duct, Common;
Humans;
Incidence;
Male;
Prognosis;
Biomarkers, Tumor;
Ultrasonography
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2002;6(1):6-11
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Intrahepatic cholangiocarcinoma, which has been defined as a primary adenocarcinoma from the intrahepatic bile ducts distal to the second-order branch of the main hepatic ducts, has a poor prognosis against various treatment modalities. We analyzed the clinical characteristics of intrahepatic cholangiocarcinomas and evaluated the outcomes of surgical treatment. METHODS: Forty five cases of microscopically-proven intrahepatic cholangiocarcinoma during 8 and a half year period from January 1993 to june 2001 were reviewed. RESULTS: They comprised 29 men and 16 women with an average age of 54.3 years (range: 34 to 76 years). The overall incidence of intrahepatic cholangiocarcinoma in association with hepatolithiasis was 4~% and in this sutdy 17 out of 45 cases (37.8%) of intrahepatic cholangiocarcinoma was combined with intrahepatic stones. The incidence of accurate preoperative diagnosis was 56% due to low index of suspicion. The growth pattern of intrahepatic cholangiocarcinoma was mass-forming type in 32 cases, periductal infiltrative type in 9 cases, and intraductal growth type in 4 cases. CONCLUSION: Careful preoperative evaluation using computed tomography, ultrasonography, and angiography and a study of tumor markers for the possibility of a intrahepatic cholangiocarcinoma is necessary in risk groups with hepatolithiasis or clonorchiasis. Hepatric resection should be used in hepatolithiasis patients to improve the chance of survival.
