Statin-Naïve Paraneoplastic Anti-HMGCR Myopathy
10.46518/kjnmd.2021.13.1.15
- Author:
Youngbok YUNG
1
;
Bo Young KIM
;
Kichang OH
;
Joong-Yang CHO
Author Information
1. Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea
- Publication Type:Case Report
- From:
Korean Journal of Neuromuscular Disorders
2021;13(1):15-19
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (anti-HMGCR) myopathy is a subtype of immune-mediated necrotizing myopathy regardless of exposure to statins. Necrotizing myopathy is distinguished by necrotic muscle fibers with a relative lack of inflammation. It is frequently associated with a high risk of permanent muscle damage and disability. Recent studies have suggested a slightly increased risk of cancer in patients with anti-HMGCR myopathy. This report describes a case of statin-naïve paraneoplastic anti-HMGCR myopathy, with rapidly progressive muscle weakness leading to respiratory failure.
