Interpretation of Anti-Nuclear Antibody Tests
10.3904/kjm.2021.96.4.337
- Author:
Chang-Nam SON
1
;
Sang-Hyon KIM
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea
- Publication Type:19
- From:Korean Journal of Medicine
2021;96(4):337-340
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-nuclear antibodies (ANAs) are autoantibodies against nuclear substances or other cellular components. ANA tests are used in the diagnostic process to screen patients with suspected rheumatic or autoimmune diseases. ANA-associated diseases are characterized by a high titer of antinuclear antibodies and include systemic lupus erythematosus, systemic sclerosis, and mixed connective tissue diseases. ANA test results must be cautiously interpreted as they can be positive not only in infections and oncological diseases but also for the healthy general population. The ANA test mainly uses the indirect immunofluorescence test, and the results are expressed in terms of the final titer and pattern. The ANA test can increase diagnostic value when used in conjunction with the evaluation of disease-related clinical symptoms.
