Age and Tumor Size is a Prognostic Factor in Pediatric/Adolescent Differentiated Thyroid Carcinoma
10.21593/kjhno/2020.36.2.9
- Author:
Byung Hyun BYUN
1
;
Guk Haeng LEE
;
Dong Ho KIM
;
Jung Sub LIM
;
Ilhan LIM
;
Sang Moo LIM
;
Byeong Cheol LEE
;
Jun Ah LEE
Author Information
1. Department of Nuclear Medicine, Korea Cancer Center Hospital, Seoul, Korea
- Publication Type:Original Article
- From:
Korean Journal of Head and Neck Oncology
2020;36(2):9-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Background/Objectives:To analyze the clinical characteristics of differentiated thyroid cancer (DTC) in children and adolescents.Materials & Methods: Medical records of 31 DTC cases that were diagnosed and treated at Korea Cancer Center Hospital between 2002 and 2018 were retrospectively reviewed.
Results:Most cases were papillary carcinoma (n=26), with female predominance (n=25). Median age was 16.4 years (range, 11.9-18.6 years). Extrathyroidal extension was present in 24 cases. Twenty cases had tumor involvement at cervical lymph nodes and three had lung metastasis. Twenty-two patients received radioactive iodide treatment with a median cumulative dose of 300 mCi (range, 100-920 mCi). During a median follow-up of 68.2 months (range, 2.3-191.4 months), serum thyroglobulin level was elevated in 15 patients. Among them, two cases had remnant thyroid tissue, 4 had recurrence at cervical lymph nodes, and the remaining 9 did not have any detectable lesion. All were alive, and 5-year event-free survival (EFS) was 45.2±10.1%. Age £15 years, tumor size, lymph node status (N1b), and distant metastasis had negative effects on EFS. On multivariate analysis, age and tumor size had prognostic significance.
Conclusion:For DTC of children and adolescents (£18 years old), age ≤15 years and tumor size were prognostic factor. Therefore, patients in this age group need meticulous follow-up. Further studies are necessary to answer the potential influence of age on the incidence and behavior of DTC.
