Syringocystadenocarcinoma Papilliferum in Situ Secondary to Scalp Nevus Sebaceus
- Author:
Dea Kwan YUN
1
;
Uri SHON
;
Gi Hyun SEONG
;
Dong Yoon LEE
;
Misoo CHOI
;
Myung Hwa KIM
;
Byung Cheol PARK
Author Information
1. Department of Dermatology, Dankook University College of Medicine, Cheonan, Korea
- Publication Type:Case Report
- From:Korean Journal of Dermatology
2021;59(6):483-486
- CountryRepublic of Korea
- Language:English
-
Abstract:
Syringocystadenocarcinoma papilliferum in situ is extremely rare. A 51-year-old female presented with a solitary yellowish patch on the scalp, accompanied by hair loss and a protruding mass. Histopathological evaluation revealed a large number of sebaceous glands and mild papillomatosis without hair follicles. The tumor contained many cystic spaces filled with amorphous material and a connection to the epidermis. The tumor cells showed papillomatous projections and were multilayered with nuclear atypia but no dermal involvement or lymphovascular invasion. On immunohistochemical analysis, the tumor cells showed immunopositivity for carcinoembryonic antigen, Ki-67, epithelial membrane antigen, and gross cystic disease fluid protein-15. Therefore, the patient was diagnosed with syringocystadenocarcinoma papilliferum in situ originating from a nevus sebaceus. The tumor was removed by wide excision, and no recurrence was observed. Our case report supports the multistep pathogenesis of syringocystadenocarcinoma papilliferum originating from a nevus sebaceus.
