Sustained antibacterial effects of antibacterial agents against Streptococcus mutans applied on hydroxyapatite disc
10.14815/kjdm.2020.47.4.245
- Author:
Ju-Lee SON
1
;
SSun IM
;
Dong-Hyun GIM
;
Seunghan OH
;
Ji-Myung BAE
Author Information
1. Department of Dental Hygiene, Wonkwang Health Science University, Iksan-si, Republic of Korea
- Publication Type:Original Article
- From:
Korean Journal of Dental Materials
2020;47(4):245-252
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to evaluate the antibacterial activities sustainability of antibacterial agents mixed with experimental fluoride varnish on hydroxyapatite disc against Streptococcus mutans (S. mutans). On the hydroxyapatite disc with 4.8 mm of diameter, 5 μL of 1 mM antibacterial agents mixed with experimental fluoride varnish were applied. Positive control and vehicle control were 10 μg/mL ampicillin and dimethyl sulfoxide (DMSO) mixed with fluoride varnish, respectively. The discs were stored in distilled water in a 37℃ shaking water bath at 120 rpm for 30 minutes, 4 hours, 1 day, 5 days, 20 days, and 30 days. Antibacterial activities were evaluated with the inhibition zone by the agar diffusion test. The antibacterial activities of all antibacterial agents were sustained for 30 days. Among them, Bakuchiol, Bavachromene, and Bavachalcone showed higher antibacterial activities for up to 30 days. The antibacterial agents when mixed in the experimental fluoride varnish with increased and prolonged antibacterial activities can be applied to prevent dental caries effectively.
