Rare ABO Allele Encoding Glycosyltransferase with Dual Specificity Found in a Cambodian Individual with the A 2 B Phenotype
10.17945/kjbt.2020.31.3.254
- Author:
HongBi YU
1
;
Yoo Na CHUNG
;
Tae Yeul KIM
;
Eunsang SUH
;
Kwang Mo CHOI
;
Duck CHO
Author Information
1. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea
- Publication Type:Case Report
- From:Korean Journal of Blood Transfusion
2020;31(3):254-259
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cis-AB and B(A) alleles encode an ABO enzyme with dual A and B glycosyltransferase activity. Although globally rare, the cis-AB phenotype is found relatively often in Korean, Japanese, and Chinese populations. Cases of the B(A) allele have been reported mostly in the Chinese population. Forward typing performed in a Cambodian woman with an ABO discrepancy demonstrated a strong reaction with anti-A and anti-B reagents, while there was no reaction with lectin anti-A 1. The anti-A 1 antibody was detected in reverse typing. Through ABO gene sequence analyses of exons 6 and 7, one of the alleles was identified as ABO*B.01. In contrast, the other allele harboring a c.803G＞C substitution was either ABO*cisAB.05 or ABO*BA.06 allele. The ABO*cisAB.05 and ABO*BA.06 alleles remain indistinguishable despite routine serological testing and ABO genotyping. To the best of the author’s knowledge, this is the first case report of these variants discovered in a Cambodian individual residing in Korea.
