Current Pharmacogenetics in Psychiatry
10.22857/kjbp.2021.28.1.001
- Author:
Il Bin KIM
1
;
Yu Sang LEE
Author Information
1. Department of Psychiatry, Hanyang University Guri Hospital, Guri, Korea
- Publication Type:REVIEW ARTICLE
- From:Journal of the Korean Society of Biological Psychiatry
2021;28(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pharmacogenetics is opening a new era of precision medicine in psychiatry. Drug-metabolizing enzymes are characterized by genetic polymorphisms, which render a large portion of variability in individual drug metabolism. Dose adjustment based on pharmacogenetics knowledge is a first step to translate pharmacogenetics into clinical practice. However, diverse factors including cost-effectiveness should be addressed to provide clinical recommendation. To address current challenges in pharmacogenetics testing in psychiatry, this review provides an update regarding genotyping (SNP analysis, array, and next-generation sequencing), genotype-phenotype correlations, and cost-effectiveness. The current updates on pharmacogenetics in psychiatry will provide guidance for both clinician and researchers to have a consensus in harmonizing efforts to advance the pharmacogenetics field in a part of precision medicine in psychiatry.
