Increased Serum Thymus and Activation-regulated Chemokine (TARC) Levels in Children with Atopic Dermatitis.
- Author:
Tae Won SONG
1
;
Byung Chul KWON
;
Sung Yon CHOI
;
Yoon Ho SHIN
;
Kyung Eun LEE
;
Hea Sun YANG
;
Kyung Won KIM
;
Eun Soo KIM
;
Myung Hyun SOHN
;
Kyu Earn KIM
Author Information
1. Department of Pediatrics and Institute of Allergy, BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kekim@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
Thymus and activation-regulated chemokine;
chemokine;
Scoring atopic dermatitis;
IgE mediated atopic dermatitis;
Non-IgE mediated atopic dermatitis
- MeSH:
Chemokine CCL17*;
Child*;
Dermatitis, Atopic*;
Eosinophils;
Humans;
Immunoglobulin E;
Inflammation;
Lymphocytes;
Thymus Gland*
- From:Pediatric Allergy and Respiratory Disease
2005;15(3):250-256
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Thymus and activation-regulated chemokine (TARC) is responsible for the trafficking of Th2 lymphocytes into sites of allergic inflammation. We tested whether TARC is a useful marker for childhood atopic dermatitis (AD) and we evaluated age-related differences in the level of TARC. METHODS: Serum TARC level, serum total IgE level, total eosinophil count and specific IgE level were measured in 401 children. They were characterized as having IgE-mediated atopic dermatitis (n=157), non-IgE mediated atopic dermatitis (n=107), or as healthy control subjects (n=137). RESULTS: TARC levels in AD significantly were higher than those in healthy control subjects. (152.9+/-11.6 vs 56.7+/-5.2 pg/mL, P< 0.05) Serum TARC levels significantly correlated with disease severity (SCORAD index) both in children with IgE mediated AD (r=0.670, P< 0.05) and children with non-IgE mediated AD. (r=0.605, P< 0.05) Serum TARC levels in control subjects decreased in accordance with age. (r=-0.201, P< 0.05) CONCLUSION: Serum TARC might be a useful marker for disease severity both in children with IgE mediated AD and children with non-IgE mediated AD. Serum TARC levels in control subjects decreased in accordance with ages.
