The relationship between leptin adiponectin ratio and insulin resistance in healthy children.
10.3345/kjp.2008.51.3.256
- Author:
Gae Hyun AHN
1
;
Shin Hye KIM
;
Eun Gyong YOO
Author Information
1. Department of Pediatrics, College of Medicine, Pochon CHA University, Seongnam, Korea. pedyoo@cha.ac.kr
- Publication Type:Original Article
- Keywords:
Leptin;
Adiponectin;
Insulin resistance;
Children
- MeSH:
Adipokines;
Adiponectin;
Child;
Estradiol;
Fasting;
Glucose;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Leptin;
Obesity;
Plasma;
Testosterone
- From:Korean Journal of Pediatrics
2008;51(3):256-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Leptin and adiponectin are two representative adipocytokines. Leptin increases, but adiponectin decreases, with obesity and insulin resistance. We aimed to study the relationship between the leptin/adiponectin ratio and insulin resistance in healthy children. METHODS: Seventy-seven healthy children (36 boys and 41 girls) were enrolled in this study. Anthropometric measurements were performed, and the percentage of weight for height (%WFH) was calculated in each subject. Fasting plasma levels of glucose, insulin, leptin, adiponectin, testosterone, estradiol, and sex-hormone binding globulin (SHBG) were measured. The free androgen index (FAI) was used as a representative of testosterone bioactivity. The homeostasis model assessment was used to estimate the degree of insulin resistance (HOMA-IR). RESULTS: In the boys, HOMA-IR was significantly correlated with age, pubertal stage, free androgen index (FAI), leptin, and the leptin/adiponectin ratio. HOMA-IR was also significantly related to age, percentage of weight for height (%WFH), pubertal stage, estradiol, leptin, and the leptin/adiponectin ratio in girls. The leptin/adiponectin ratio was independently related to HOMA-IR after adjusting for age, %WFH, and FAI in the boys (P<0.05). The leptin/adiponectin ratio was not independently related to HOMA-IR after adjusting for age, %WFH, and estradiol in girls. CONCLUSION: In non-obese healthy children, the leptin/adiponectin ratio was significantly correlated with insulin resistance. The leptin/adiponectin ratio was independently related to insulin resistance even after adjusting for age, degree of obesity, and androgen levels in healthy boys.
