Factors Affecting Prognosis of Temporal Lobe Epilepsy.
- Author:
Ok Joon KIM
1
;
Jang Sung KIM
;
Byung In LEE
Author Information
1. Department of Neurology, Pochon CHA University, College of Medicine.
- Publication Type:Original Article
- Keywords:
Epilepsy/Temporal lobe;
Anticonvulsants;
Prognosis
- MeSH:
Anticonvulsants;
Cohort Studies;
Epilepsy;
Epilepsy, Temporal Lobe*;
Humans;
Polypharmacy;
Prognosis*;
Prospective Studies;
Seizures;
Temporal Lobe*
- From:Journal of the Korean Neurological Association
2000;18(5):601-608
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Although the poor short-term outcome of antiepileptic drug (AED) treatment may represent long-term AED refractoriness in general, the same hypothesis in temporal lobe epilepsy (TLE) has yet to come up as an important subject to be investigated. We examined to decide early drug intractability and aid treatment plan. METHODS: From a prospective patient cohort of Yonsei Epilepsy Clinic, 121 newly-referred TLE patients were selected to participate in this study. First, we divided the patients into two groups according to their second one-year remission at two year of AED treatment. One group was the remission group (RG) and the other was the non-remission group (NRG). Second, we evaluated clinical characteristics influencing remission between the two groups. RESULTS: Nineteen patients (15.7%) were RG whereas 102 (84.3%) were NRG. The six month remission and terminal remission at the first year of AED treatment and the first one year remission rate in patients with RG was significantly higher than those with NRG (P<0.05). In patients with NRG, the number of complex partial seizures and secondary generalized seizures, the annual frequency of secondary generalized seizures prior to AED treatment, polypharmacy, new drug use, and drug side effects were significantly higher (p<0.05) than RG. CONCLUSIONS: The earlier seizure outcome may influence the later prognosis of AED treatment in non-lesional TLE. The prognosis during the second year of AED treatment is influenced by drug treatment and the number of generalized seizures.
