Zebrafish Vascular Development: General and Tissue-Specific Regulation
10.12997/jla.2021.10.2.145
- Author:
Hiroyuki NAKAJIMA
1
;
Ayano CHIBA
;
Moe FUKUMOTO
;
Nanami MOROOKA
;
Naoki MOCHIZUKI
Author Information
1. Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan
- Publication Type:Review
- From:Journal of Lipid and Atherosclerosis
2021;10(2):145-159
- CountryRepublic of Korea
- Language:English
-
Abstract:
Circulation is required for the delivery of oxygen and nutrition to tissues and organs, as well as waste collection. Therefore, the heart and vessels develop first during embryogenesis.The circulatory system consists of the heart, blood vessels, and blood cells, which originate from the mesoderm. The gene expression pattern required for blood vessel development is predetermined by the hierarchical and sequential regulation of genes for the differentiation of mesodermal cells. Herein, we review how blood vessels form distinctly in different tissues or organs of zebrafish and how vessel formation is universally or tissue-specifically regulated by signal transduction pathways and blood flow. In addition, the unsolved issues of mutual contacts and interplay of circulatory organs during embryogenesis are discussed.
