Antibody Responses One Year after Mild SARS-CoV-2 Infection
10.3346/jkms.2021.36.e157
- Author:
Pyoeng Gyun CHOE
1
;
Kye-Hyung KIM
;
Chang Kyung KANG
;
Hyeon Jeong SUH
;
EunKyo KANG
;
Sun Young LEE
;
Nam Joong KIM
;
Jongyoun YI
;
Wan Beom PARK
;
Myoung-don OH
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
- Publication Type:Brief Communication
- From:Journal of Korean Medical Science
2021;36(21):e157-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.
