Multifocal Electroretinogram Findings after Intravitreal Bevacizumab Injection in Choroidal Neovascularization of Age-Related Macular Degeneration.
10.3341/kjo.2011.25.3.161
- Author:
Joo Youn PARK
1
;
Seung Hoon KIM
;
Tae Kwann PARK
;
Young Hoon OHN
Author Information
1. Department of Ophthalmology, Soonchunhyang University College of Medicine, Bucheon, Korea. yhohn@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Age-related macular degeneration;
Bevacizumab;
Choroidal neovascularization;
Multifocal electroretinogram;
Optical coherence tomography
- MeSH:
Adult;
Aged;
Angiogenesis Inhibitors/*administration & dosage;
Antibodies, Monoclonal/*administration & dosage;
Choroidal Neovascularization/*drug therapy/*etiology;
Electroretinography/*methods;
Eyeglasses;
Humans;
Intravitreal Injections;
Macular Degeneration/*complications/diagnosis/physiopathology;
Middle Aged;
Retina/drug effects/physiopathology;
Tomography, Optical Coherence;
Visual Acuity
- From:Korean Journal of Ophthalmology
2011;25(3):161-165
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the changes in multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) after intravitreal bevacizumab injection in the treatment of age-related macular degeneration (AMD). METHODS: Twenty-one eyes with choroidal neovascularization secondary to AMD were studied before and after intravitreal bevacizumab injection for best corrected visual acuity (BCVA), OCT, and mfERG. RESULTS: The BCVA improved, while central macular thickness and total macular volume in OCT decreased after intravitreal bevacizumab injection (p = 0.03, 0.01, and 0.01, respectively). In mfERG, the amplitude of P1, and implicit time of P1 and N1 indicated a statistically significant improvement of retinal response after intravitreal bevacizumab injection. CONCLUSIONS: There is a potential role for mfERG in evaluating the effect on retinal function of intravitreal bevacizumab injection.
