Thrombolytic Therapy for Repeated Prosthetic Valvular Thrombosis That's Associated with Pregnancy under Heparin Anticoagulation.
- Author:
Ju Won CHOE
1
;
Yong In L KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Chung-Ang University Yongsan Hospital, Chung-Ang University College of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
Anticoagulants;
Thrombolysis;
Heparin;
Antithrombin III;
Prosthesis failure
- MeSH:
Anticoagulants;
Antithrombin III;
Heparin;
Humans;
Pregnancy;
Prostheses and Implants;
Prosthesis Failure;
Thrombolytic Therapy;
Thrombosis;
Tissue Plasminogen Activator;
Urokinase-Type Plasminogen Activator
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2008;41(4):484-488
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
During long-term anticoagulation treatment with using heparin in a pregnant patient with a mechanical mitral prosthesis, we observed several anticoagulation-related complications, including repeated prosthetic valve thrombosis. This was found to be caused by heparin resistance due to an anti-thrombin III deficiency. Thrombolytic therapy using urokinase or tissue plasminogen activator (tPA) was successful and safe for her as well as her baby.
