Serum Uric Acid is Associated with Cardiovascular Events in Patients with Coronary Artery Disease.
10.4070/kcj.2007.37.4.161
- Author:
Jang Ho BAE
1
;
Dae Woo HYUN
;
Taek Geun KWON
;
Hyun Ju YOON
;
Amir LERMAN
;
Charanjit S RIHAL
Author Information
1. Division of Cardiology, Konyang University Hospital, Daejeon, Korea. janghobae@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Uric acid;
Coronary artery disease;
Prognosis
- MeSH:
Acute Coronary Syndrome;
Coronary Artery Bypass;
Coronary Artery Disease*;
Coronary Vessels*;
Death, Sudden, Cardiac;
Follow-Up Studies;
Heart Failure;
Humans;
Myocardial Infarction;
Percutaneous Coronary Intervention;
Prognosis;
Stroke;
Transplants;
Uric Acid*
- From:Korean Circulation Journal
2007;37(4):161-166
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Whether uric acid is a predictor of cardiovascular events remains controversial. We sought to evaluate the effects of the serum uric acid levels on major adverse cardiovascular events (MACEs) in the patients with coronary artery disease (CAD). SUBJECTS AND METHODS: The study population consisted of 660 consecutive patients with CAD, and they were followed up for a mean of 27 months (maximum: 62 months). The recorded MACEs included acute myocardial infarction (AMI), stroke, coronary artery bypass graft, percutaneous coronary intervention (PCI) due to de novo lesion during follow up, congestive heart failure (CHF) and sudden cardiac death. RESULTS: In the CAD patients with a uric acid level < or =3.88 mg/dL (the lowest quartile), as compared with those CAD patients with uric acid levels >5.74 mg/dL (the highest quartile), the MACE rate increased from 7.2% to 20.1%. On univariate Cox regression analysis, the highest uric acid quartile was a predictor of AMI, CHF and MACE. The absolute serum uric acid level was predictive of PCI, CHF and MACE. Multivariate Cox regression analysis showed that the independent predictors of MACE were presentation with acute coronary syndrome (HR 1.70, 95% CI: 1.04 to 2.78, p=0.033), multi-vessel disease (HR 2.43, 95% CI: 1.44 to 4.12, p=0.001), and the uric acid levels (HR 1.22, 95% CI: 1.05 to 1.43, p=0.010), and the highest uric acid quartile (HR 2.54, 95% CI: 1.58 to 4.10, p<0.001). CONCLUSION: The serum uric acid level and multi-vessel disease are associated with subsequent cardiovascular events in the patients with CAD.
