Insulin-Like Growth Factor 1 Actions in Developing Brain and the Interaction with Wnt Pathway.
10.6065/apem.2012.17.1.10
- Author:
Seong Yong LEE
1
Author Information
1. Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea. gnoygnoes@hanmail.net
- Publication Type:Review
- Keywords:
Insulin-like growth factor I;
Type 1 IGF receptor;
Wnt proteins;
Beta catenin;
Central nervous system
- MeSH:
beta Catenin;
Brain;
Central Nervous System;
Frizzled Receptors;
Glycogen Synthase Kinase 3;
Growth and Development;
Insulin;
Insulin-Like Growth Factor I;
Ligands;
Myelin Sheath;
Neural Stem Cells;
Neurons;
Oligodendroglia;
Phosphatidylinositol 3-Kinase;
Phosphotransferases;
Wnt Proteins;
Wnt Signaling Pathway
- From:Annals of Pediatric Endocrinology & Metabolism
2012;17(1):10-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Insulin like growth factor (IGF)-1 signaling through type 1 IGF receptor (IGF1R) is essential to the normal growth and development of the central nervous system. IGF-1 stimulates proliferation of neural stem cells and neural progenitors. IGF-1 also promotes survival and differentiation of neurons and oligodendrocytes, including neuritic outgrowth, synaptogenesis, and myelin production. The phosphatidylinositol 3 kinase (PI3)-Akt pathway and mitogen-activated protein (MAP) kinase pathway are two predominant mediators of IGF1-IGF1R signaling in neural cells. beta-catenin, a key molecule of the canonical Wnt signaling pathway, is also a downstream target of PI3-Akt-glycogen synthase kinase 3beta (GSK3beta) pathway. IGF-1 signaling through IGF1R interacts with canonical Wnt pathway at the levels of GSK3beta and beta-catenin rather than at the levels of Wnt ligands and Frizzled receptors to promote neural proliferation in developing central nervous system.
