Serum Alkaline Phosphatase Levels in 10-20 Year Old Healthy Korean Children and Adolescents: Based on the 2009 Korean National Health and Nutrition Examination Survey.
10.6065/apem.2012.17.1.39
- Author:
Ji Young SEO
1
;
Jeong Don CHAE
;
Hong Kyu PARK
;
Dong Ho KIM
;
Jun Ah LEE
;
Jung Sub LIM
Author Information
1. Department of Pediatrics, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Alkaline phosphatase;
Reference values;
Korean;
Child;
Adolescent;
Sex characteristics
- MeSH:
Adolescent;
Adult;
Alkaline Phosphatase;
Buffers;
Child;
Humans;
Nutrition Surveys;
Reference Values;
Rickets;
Sex Characteristics;
Vitamin D Deficiency
- From:Annals of Pediatric Endocrinology & Metabolism
2012;17(1):39-44
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Serum alkaline phosphatase (sALP) levels show great variation with age and sex in children and adolescents. We aimed to study pediatric age- and sex-specific reference ranges for sALP and how the pattern changed according to age . METHODS: Cross-sectional results from 1366 healthy Korean children and adolescents (10-19.9 years) from the Korean National Health and Nutrition Examination Survey were analyzed. We constructed age- and sex-specific reference data for sALP with a Hitachi Automatic Analyzer 7600 using Pureauto S ALP. We assessed its peak both in relation to age. RESULTS: Reference values for sALP according to age were constructed. Peak sALP levels were found at 12-13 years in boys (P < 0.001). Total sALP levels decreased to the adult level at the age of 17 in boys and 15 in girls, respectively. CONCLUSION: This study provides reference values for sALP by age for Korean children and adolescents. This normative data that includes upper and lower limits will provide a basis from which to better evaluate sALP levels, especially for bone disorders such as rickets and vitamin D deficiency. However, caution should be made in interpreting sALP levels because different buffers might lead to different values in the same serum.
