Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the SongpaKangdong District of Seoul, Korea
- Author:
Sang Hyoung PARK
1
;
Seung Kyu JEONG
;
Ji Hyun LEE
;
Kyoung Hoon RHEE
;
Young-Ho KIM
;
Sung Noh HONG
;
Kyung Ho KIM
;
Seung In SEO
;
Jae Myung CHA
;
Sun Yong PARK
;
Hyunju PARK
;
Joo Sung KIM
;
Jong Pil IM
;
Hyuk YOON
;
Sung Hoon KIM
;
Jisun JANG
;
Jeong Hwan KIM
;
Seong O SUH
;
Young Kyun KIM
;
Byong Duk YE
;
Suk-Kyun YANG
;
Author Information
- Publication Type:Original Article
- From:Gut and Liver 2021;15(5):742-751
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background/Aims:We aimed to evaluate the clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using a wellestablished population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
Methods:Clinical characteristics and prognosis were compared between two groups: EOUC,defined as UC diagnosed in individuals aged ≥60 years and non-EOUC (N-EOUC), defined asUC diagnosed in individuals aged 18 to 59 years.
Results:We identified 99 patients with EOUC (10.3%) and 866 patients with N-EOUC (89.7%) between 1986 and 2015. During the median follow-up of 104.5 months, the overall exposure tomedications was comparable between patients with EOUC and N-EOUC (p=0.091 for corticosteroids, p=0.794 for thiopurines, and p=0.095 for anti-tumor necrosis factor agents). The cumula-tive risks of disease outcomes were also comparable between patients with EOUC and N-EOUC (22.4% vs 30.4% for proximal disease extension [p=0.351], 11.9% vs 18.1% for hospitalization [p=0.240], and 2.3% vs 1.8% for colectomy [p=0.977]) at 10 years after diagnosis. Multivariate Cox regression analysis revealed that corticosteroid use at diagnosis was an independent predic-tor of proximal disease extension (hazard ratio [HR], 6.216; 95% confidence interval [CI], 1.314 to 28.826) and hospitalization (HR, 11.241; 95% CI, 3.027 to 41.742) in patients with EOUC.
Conclusions:In this population-based study from Korea, the pattern of medication use seemed comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those with N-EOUC have a similar disease course in terms of proximal disease extension, hospitaliza-tion, and colectomy.
