The ceRNA network of lncRNA and miRNA in lung cancer
- Author:
Danbi SEO
1
;
Dain KIM
;
Yeonsoo CHAE
;
Wanyeon KIM
Author Information
- Publication Type:Review article
- From:Genomics & Informatics 2020;18(4):e36-
- CountryRepublic of Korea
- Language:English
- Abstract: Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies have been continuously conducted. Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are being exponentially studied as promising biomarkers of lung cancer. Moreover, supportive evidence provides the competing endogenous RNA (ceRNA) network between lncRNAs and miRNAs participating in lung tumorigenesis. This review introduced the oncogenic or tumor-suppressive roles of lncRNAs and miRNAs in lung cancer cells and summarized the involvement of the lncRNA/miRNA ceRNA networks in carcinogenesis and therapeutic resistance of lung cancer.
