High Levels of IL-8 and MCP-1 in Cerebrospinal Fluid of COVID-19 Patients with Cerebrovascular Disease
- Author:
Sebastián GUARTAZACA-GUERRERO
1
;
Jahir RODRÍGUEZ-MORALES
;
Salma A. RIZO-TÉLLEZ
;
Helena SOLLEIRO-VILLAVICENCIO
;
Aldo F. HERNÁNDEZ-VALENCIA
;
José Damián CARRILLO-RUIZ
;
Galileo ESCOBEDO
;
Lucía A. MÉNDEZ-GARCÍA
Author Information
- Publication Type:Case Report
- From:Experimental Neurobiology 2021;30(3):256-261
- CountryRepublic of Korea
- Language:English
- Abstract: The coronavirus family has tropism for the Central Nervous System (CNS), however, there is no solid evidence demonstrating that the neurological effects of COVID-19 result from direct viral infection or systemic inflammation. The goals of this study were to examine the cytokine profile and the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) in cerebrospinal fluids (CSF) from two patients with cerebrovascular disease and COVID-19. Although the SARS-CoV-2 mRNA was not detected in CSF of both patients, we found abnormally high levels of numerous proinflammatory cytokines and chemokines, especially IL-8 and MCP-1. Since these chemokines mediate activation and recruitment of neutrophils, monocytes, and macrophages, it is feasible that cerebrovascular disease related-neuroinflammation found in both patients results from an exacerbated inflammatory response instead of SARS-CoV-2 direct invasion to CNS. These results suggest that neuroinflammation plays a key role in cerebrovascular disease and COVID-19.
