Human papillomavirus: footprints in the population of western India
- Author:
Ashi Robert THOBIAS
1
;
Kinjal Ankit PATEL
;
Supreet Dhananjay BHATT
;
Kruti Ashvinkumar MEHTA
;
Chetana Deepal PAREKH
;
Pariseema Sharad DAVE
;
Prabhudas Shankarbhai PATEL
Author Information
- Publication Type:Original Article
- From:Epidemiology and Health 2021;43(1):e2021013-
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES:Cancer is a multi-factorial disease, with various intrinsic and environmental factors contributing to its occurrence. Human papillomavirus (HPV) has been associated with the occurrence of many cancers. India severely suffers from 3 HPV-associated cancers (cervical cancer, oral cancer, and oropharyngeal cancer). Hence, the present study aimed to evaluate the HPV burden in these 3 cancers among patients from the western region of India.
METHODS:DNA was isolated from samples from 400 cervical cancer, 127 oral cancer, and 75 oropharyngeal cancer patients. Polymerase chain reaction was performed using degenerate primers for HPV infection.
RESULTS:Overall, HPV infection was observed in 87% of cervical cancer cases, 12.5% of oral cancer cases, and 26.7% of oropharyngeal cancer cases when analyzed with a cumulative detection method using the MY 09/11, GP 5+/6+, and CP I/II primer sets.
CONCLUSIONS:A significant prevalence of HPV infection was detected in all 3 cancers using the degenerate primer sets. This finding implies that testing for HPV infection using multiple primer sets is crucial for determining its actual prevalence in various malignancies.
