Immunopathologic Study and Clinical Correlation of Non-Hodgkin's Lymphoma.
- Author:
Mi Seon LEE
;
Jin Man KIM
;
Kwang Sun SUH
;
Dae Young KANG
- Publication Type:Original Article
- Keywords:
Monoclonal antibodies;
B-cell lymphoma;
T-cell lymphoma;
Polymorphic reticulosis
- From:Korean Journal of Pathology
1991;25(5):407-417
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In Korea, the proportion of B-cell and T-cell lymphomas has not yet been clearly estimated. In the present study, we analysed clinicopathologic and immunophenotypic findings in 60 cases of non-Hodgkin's lymphomas(NHL) and in 17 cases of polymorphic reticulosis. Immunohistochemical studies for monoclonal antibodies, such as MB2, UCHL-1, Kappa/Lambda light chains, and IgG/IgM/IgD heavy chains were performed on formaldehyde-fixed paraffin embedded tissue sections. Among 60 cases of NHL, 28 cases(46.7%) expressed B-cell markers, 29 cases(48.3%) T-cell markers, and 3 cases(5.0%) lacked detectable markers, whereas 16 of 17 cases(94.2%) of polymorphic reticulosis reacted with T-cell markers. The mean survival of the 16 cases of T-cell lymphoma group was shorter than that of the lymphoma group positive for B-cell markers.
