Parkinson's Disease with Fatigue: Clinical Characteristics and Potential Mechanisms Relevant to α-Synuclein Oligomer.
10.3988/jcn.2016.12.2.172
- Author:
Li Jun ZUO
1
;
Shu Yang YU
;
Fang WANG
;
Yang HU
;
Ying Shan PIAO
;
Yang DU
;
Teng Hong LIAN
;
Rui Dan WANG
;
Qiu Jin YU
;
Ya Jie WANG
;
Xiao Min WANG
;
Piu CHAN
;
Sheng Di CHEN
;
Yongjun WANG
;
Wei ZHANG
Author Information
1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
- Publication Type:Original Article
- Keywords:
Parkinson's disease;
fatigue;
motor symptoms;
nonmotor symptoms;
α-synuclein oligomer;
cerebrospinal fluid
- MeSH:
Anxiety;
Cerebrospinal Fluid;
Depression;
Fatigue*;
Humans;
Linear Models;
Parkinson Disease*;
Weights and Measures
- From:Journal of Clinical Neurology
2016;12(2):172-180
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND PURPOSE: The aim of this study was to identify the clinical characteristics and potential mechanisms relevant to pathological proteins in Parkinson's disease (PD) patients who experience fatigue. METHODS: PD patients (n=102) were evaluated using a fatigue severity scale and scales for motor and nonmotor symptoms. The levels of three pathological proteins-α-synuclein oligomer, β-amyloid (Aβ)(1-42), and tau-were measured in 102 cerebrospinal fluid (CSF) samples from these PD patients. Linear regression analyses were performed between fatigue score and the CSF levels of the above-listed pathological proteins in PD patients. RESULTS: The frequency of fatigue in the PD patients was 62.75%. The fatigue group had worse motor symptoms and anxiety, depression, and autonomic dysfunction. The CSF level of α-synuclein oligomer was higher and that of Aβ1-42 was lower in the fatigue group than in the non-fatigue group. In multiple linear regression analyses, fatigue severity was significantly and positively correlated with the α-synuclein oligomer level in the CSF of PD patients, after adjusting for confounders. CONCLUSIONS: PD patients experience a high frequency of fatigue. PD patients with fatigue have worse motor and part nonmotor symptoms. Fatigue in PD patients is associated with an increased α-synuclein oligomer level in the CSF.
