Clinical significance and prognostic value of C-reactive protein/albumin ratio in gastric cancer
10.4174/astr.2021.100.6.338
- Author:
Qian YU
1
;
Ke-zhi LI
;
Yan-jun FU
;
Yanping TANG
;
Xin-qiang LIANG
;
Zhi-qing LIANG
;
Ji-hong BAI
Author Information
1. Department of Pharmaceutics, Affiliated Hospital of Guilin Medical University, Guilin, China
- Publication Type:ORIGINAL ARTICLE
- From:Annals of Surgical Treatment and Research
2021;100(6):338-346
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:This study was aimed to evaluate the clinical significance and prognostic value of CRP/albumin ratio (CAR) in patients with gastric cancer.
Methods:The data of 205 gastric cancer patients who underwent surgery was analyzed retrospectively. The association of CAR with the clinical features and prognostic value in gastric cancer was analyzed. The data of this study was combined with previous studies to further determine the prognostic value of CAR in patients with gastric cancer using a metaanalysis method.
Results:Cox analysis revealed that preoperative CAR was an independent prognosis indicator in patients with gastric cancer. High expression of CAR indicated a shorter survival time than in those with lower expression. CAR has a higher prognostic value in the 1-, 3-, and 5-year overall survival in patients with gastric cancer. CAR showed significant difference regarding the gastric cancer patients’ age, M stage, and clinical stage. The discriminate value of CAR in M stage of gastric cancer was high (area under the curve, 0.809). A meta-analysis combining previous data and our data showed that preoperative CAR demonstrated a significant association with the overall survival of patients with gastric cancer.
Conclusion:This study demonstrated that preoperative CAR could serve as an important prognostic indicator in patients with gastric cancer.
