Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks.

Author: Xiaojin CHEN ¹ ; Tao GUO ² ; Kaikai ZHANG ² ; Jiacai CHEN ² ; Caifen WANG ² ; Xiaohong REN ² ; Qin WANG ¹ ; Yingchao YANG ² ; Chongjing LIU ² ; Wen TAN ³ ; Shuangying GUI ¹ ; Li WU ² ; Jiwen ZHANG ¹
Author Information

1. Anhui University of Traditional Chinese Medicine, Anhui 230000, China.
2. Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
3. Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China.
Publication Type:Journal Article
Keywords: Bioavailability; Cyclodextrin metal-organic framework; Drug loading; Isosteviol; Molecular simulation; Nanoclusters; Solubility; Supramolecule
From: Acta Pharmaceutica Sinica B 2021;11(9):2914-2923
CountryChina
Language:English
Abstract: Cyclodextrin metal-organic framework (CD-MOF) as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol (STV). The solubility of STV was lower than 20.00 ng/mL at pH 1.0 and pH 4.5, whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and 129.58 ng/mL in water with a significant pH-dependence. The