Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRAS

Author: Cuicui LI ¹ ; Ni ZHAO ¹ ; Luyan AN ¹ ; Zhen DAI ¹ ; Xiaoyi CHEN ¹ ; Fan YANG ¹ ; Qidong YOU ¹ ; Bin DI ¹ ; Chi HU ² ; Lili XU ¹
Author Information

1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
2. Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, China.
Publication Type:Journal Article
Keywords: Cell-cycle arrest and apoptosis; KRASG12C; Non-small cell lung cancer; Stability; Stapled peptides
From: Acta Pharmaceutica Sinica B 2021;11(9):2670-2684
CountryChina
Language:English
Abstract: Lung cancers are the leading cause of cancer deaths worldwide and pose a grave threat to human life and health. Non-small cell lung cancer (NSCLC) is the most frequent malignancy occupying 80% of all lung cancer subtypes. Except for other mutations (