Influencing factors and strategies of enhancing nanoparticles into tumors

Author: Mingming ZHANG ¹ ; Shan GAO ¹ ; Dongjuan YANG ¹ ; Yan FANG ¹ ; Xiaojie LIN ¹ ; Xuechao JIN ¹ ; Yuli LIU ¹ ; Xiu LIU ¹ ; Kexin SU ¹ ; Kai SHI ¹
Author Information

1. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 117004, China.
Publication Type:Review
Keywords: Cancer-associated fibroblasts; Drug delivery; Extracellular matrix; Nanoparticles; Reticuloendothelial system; Tumor microenvironment; Tumor stroma; Tumor vascular endothelial cells
From: Acta Pharmaceutica Sinica B 2021;11(8):2265-2285
CountryChina
Language:English
Abstract: The administration of nanoparticles (NPs) first faces the challenges of evading renal filtration and clearance of reticuloendothelial system (RES). After that, NPs infiltrate through the expanded endothelial space and penetrated the dense stroma of tumor microenvironment to tumor cells. As long as possible to prolong the time of NPs remaining in tumor tissue, NPs release active agent and induce pharmacological action. This review provides a comprehensive summary of the physical and chemical properties of NPs and the influence of various biological factors in tumor microenvironment, and discusses how to improve the final efficacy through adjusting the characteristics and structure of NPs. Perspectives and future directions are also provided.