The cellular immunotherapy of integrated photothermal anti-oxidation Pd-Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis.
10.1016/j.apsb.2021.02.021
- Author:
Chuping ZHENG
1
;
Aiping WU
1
;
Xinyun ZHAI
2
;
Hong JI
1
;
Zhikang CHEN
1
;
Xu CHEN
3
;
Xiyong YU
1
Author Information
1. Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease Pharmacological Group, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China.
2. Nankai University, School of Materials Science & Engineering, Tianjin Key laboratory of Rare earth materials & applications, Center of Rare earth & Inorganic functional materials, Tianjin 300350, China.
3. The First Affiliated Hospital, Jinan University, Guangzhou 510632, China.
- Publication Type:Journal Article
- Keywords:
Anti-oxidation therapy;
Core‒shell structure;
Inflammatory response;
Photothermal therapy;
Rheumatoid arthritis
- From:
Acta Pharmaceutica Sinica B
2021;11(7):1993-2003
- CountryChina
- Language:English
-
Abstract:
Reducing the inflammatory response is a major goal in the therapy of rheumatoid arthritis (RA). Herein, we integrated palladium nanoparticles (Pd NPs) with selenium nanoparticles (Se NPs) and obtained a multiple nanosystem (Pd@Se-HA NPs) that could simultaneously scavenge hydroxyl radicals (⋅OH) and provide a photothermal effect. The Pd@Se-HA NPs were constructed by a simple self-assembly method in which Se NPs were electrostatically bonded to Pd NPs; hyaluronic acid (HA) was linked to the NPs by ester bonding to provide macrophage targeting ability. The experiments show that the combined therapy of eliminating ⋅OH with Se NPs and utilizing PTT with Pd NPs could effectively reduce the inflammatory response in macrophages more effectively than either individual NP treatment. In addition, the outer layer of HA could specifically target the CD44 receptor to enhance the accumulation of Pd@Se NPs at the lesion, further enhancing the therapeutic effect. After treatment for 15 days, the Pd@Se-HA NPs nearly eliminated the inflammatory response in the joints of mice in an induced RA model, and prevented joint damage and degradation.
