Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy.

Author: Ziyan ZHANG ¹ ; Qiaojuan LIU ² ; Jizhou TAN ³ ; Xiaoxia ZHAN ³ ; Ting LIU ³ ; Yuting WANG ² ; Gen LU ⁴ ; Minhao WU ² ; Yuanqing ZHANG ¹
Author Information

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
2. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
3. The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
4. Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou 510080, China.
Publication Type:Journal Article
Keywords: Adoptive cell therapy; Cell surface engineering; DNA nanostructure; Rolling circle amplification; Selective cytoprotection; T cell; Tetrahedral DNA nanostructure; Tumor-killing
From: Acta Pharmaceutica Sinica B 2021;11(7):1965-1977
CountryChina
Language:English
Abstract: Adoptive cell therapy (ACT) is an emerging powerful cancer immunotherapy, which includes a complex process of genetic modification, stimulation and expansion. During these