3D organoids derived from the small intestine: An emerging tool for drug transport research.
10.1016/j.apsb.2020.12.002
- Author:
Yuanjin ZHANG
1
;
Shengbo HUANG
1
;
Weiguo ZHONG
1
;
Wenxia CHEN
1
;
Bingyi YAO
1
;
Xin WANG
1
Author Information
1. Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
- Publication Type:Review
- Keywords:
3D organoid;
ASCs, adult somatic stem cells;
BCRP, breast cancer resistance protein;
BMP, bone morphogenetic protein;
CDF, 5(6)-carboxy-2′,7′-dichlorofluorescein;
Caco-2 cell monolayer;
DDI, drug–drug interactions;
Drug transporter;
EGF, epidermal growth factor;
ER, efflux ratio;
ESCs, embryonic stem cells;
FGF, fibroblast growth factor;
Lgr5+, leucine-rich-repeat-containing G-protein-coupled receptor 5 positive;
MCT, monocarboxylate transporter protein;
MRP2, multidrug resistance protein 2;
NBD, nucleotide-binding domain;
OATP, organic anion transporting polypeptide;
OCT, organic cation transporter;
OCTN, carnitine/organic cation transporter;
P-glycoprotein;
P-gp, P-glycoprotein;
PEPT, peptide transporter protein;
PMAT, plasma membrane monoamine transporter;
PSCs, pluripotent stem cells;
Papp, apparent permeability coefficient;
Rh123, rhodamine 123;
SLC, solute carrier;
Small intestine;
TEER, transepithelial electrical resistance;
TMDs, transmembrane domains;
cMOAT, canalicular multispecific organic anion transporter;
iPSCs, induced pluripotent stem cells
- From:
Acta Pharmaceutica Sinica B
2021;11(7):1697-1707
- CountryChina
- Language:English
-
Abstract:
Small intestine
