From Vietnamese plants to a biflavonoid that relieves inflammation by triggering the lipid mediator class switch to resolution.
10.1016/j.apsb.2021.04.011
- Author:
Tran Thi VAN ANH
1
;
Alilou MOSTAFA
1
;
Zhigang RAO
2
;
Simona PACE
3
;
Stefan SCHWAIGER
1
;
Christian KRETZER
3
;
Veronika TEMML
1
;
Carsten GIESEL
3
;
Paul M JORDAN
3
;
Rossella BILANCIA
4
;
Christina WEINIGEL
5
;
Silke RUMMLER
5
;
Birgit WALTENBERGER
1
;
Tran HUNG
6
;
Antonietta ROSSI
4
;
Hermann STUPPNER
1
;
Oliver WERZ
3
;
Andreas KOEBERLE
2
Author Information
1. Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.
2. Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria.
3. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, Jena 07743, Germany.
4. Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples 80131, Italy.
5. Institute of Transfusion Medicine, University Hospital Jena, Jena 07747, Germany.
6. Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Viet Nam.
- Publication Type:Journal Article
- Keywords:
12-HHT, 12(S)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid;
5-H(p)ETE, 5-hydro(pero)xy-eicosatetraenoic acid;
COX, cyclooxygenase;
DAD, diode array detector;
DPPH, 2,2-diphenyl-1-picrylhydrazyl;
ECD, electronic circular dichroism;
ESI, electrospray ionization;
FCS, fetal calf serum;
HPLC, high performance liquid chromatography;
HR, high resolution;
IFN, interferon;
IL, interleukin;
Inflammation;
LOX, lipoxygenase;
LT, leukotriene;
LTC4S, leukotriene C4 synthase;
Lipid mediator;
Lipidomics;
Lipoxygenase;
MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;
MaR, maresin;
Natural product;
PBMC, peripheral blood mononuclear cells;
PD, protectin;
PG, prostaglandin;
PMNL, polymorphonuclear neutrophils;
RP, reversed phase;
Resolution;
Rv, resolvin;
SPE, solid phase extraction;
SPM, specialized pro-resolving mediators;
TX, thromboxane;
UPLC‒MS/MS, ultra-performance liquid chromatography–tandem mass spectrometry;
mPGES-1, microsomal prostaglandin E2 synthase 1;
sEH, soluble epoxide hydrolase
- From:
Acta Pharmaceutica Sinica B
2021;11(6):1629-1647
- CountryChina
- Language:English
-
Abstract:
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolving lipid mediator biosynthesis is considered as efficient strategy to relieve chronic inflammation, though drug candidates exhibiting such features are unknown. Starting from a library of Vietnamese medical plant extracts, we identified isomers of the biflavanoid 8-methylsocotrin-4'-ol from
