HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial-mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/
10.1016/j.apsb.2021.03.040
- Author:
Wei TIAN
1
;
Jiatong LI
1
;
Zhuo WANG
1
;
Tong ZHANG
2
;
Ying HAN
1
;
Yanyan LIU
3
;
Wenfeng CHU
1
;
Yu LIU
1
;
Baofeng YANG
1
Author Information
1. Department of Pharmacology (the State-Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China.
2. The First Affiliated Hospital of Harbin Medical University, Harbin 150081, China.
3. Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin 150081, China.
- Publication Type:Journal Article
- Keywords:
Cancer stem-like cell;
HYD-PEP06;
Hepatocellular carcinoma;
PI3K/AKT;
WNT/β-catenin
- From:
Acta Pharmaceutica Sinica B
2021;11(6):1592-1606
- CountryChina
- Language:English
-
Abstract:
HYD-PEP06, an endostatin-modified polypeptide, has been shown to produce effective anti-colorectal carcinoma effects through inhibiting epithelial-mesenchymal transition (EMT). However, whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma (HCC) remained unknown. In this study, HYD-PEP06 inhibited metastasis and EMT but not proliferation
