LIX1-like protein promotes liver cancer progression
10.1016/j.apsb.2021.02.005
- Author:
Jie ZOU
1
;
Xiaoyun ZHU
1
;
Dejuan XIANG
1
;
Yanqiu ZHANG
1
;
Jie LI
1
;
Zhigui SU
2
;
Lingyi KONG
1
;
Hao ZHANG
1
Author Information
1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- Keywords:
CCl4, carbon tetrachloride;
DEN, diethylnitrosamine;
ECAR, extracellular acidification rate;
EMT, epithelial–mesenchymal transition;
FBP1;
FBP1, fructose-1,6-bisphosphatase 1;
Gluconeogenesis;
Glucose metabolism;
HCC, hepatocellular carcinoma;
Hepatocellular carcinoma;
LIX1L;
LIX1L, Limb and CNS expressed 1 like;
Metastasis;
NASH, non-alcoholic steatohepatitis;
Proliferation;
Seq, sequencing;
miR-21-3p;
miRNA, microRNA;
shRNA, short-hairpin RNA
- From:
Acta Pharmaceutica Sinica B
2021;11(6):1578-1591
- CountryChina
- Language:English
-
Abstract:
Limb and CNS expressed 1 like (LIX1L) is over-expressed in several types of tumors. However, the function of LIX1L in glucose metabolism and hepatocellular carcinoma (HCC) progression remains elusive. Here we report that LIX1L is over-expressed in human HCC tissues, which predicts unfavorable prognosis. LIX1L deficiency
